HIV Target gene Detail Information

> PHC3 Gene Search Result

Gene Information

Gene Name	PHC3
Gene ID	80012
Gene Full Name	polyhomeotic homolog 3
Gene Alias	EDR3; HPH3
Transcripts	ENSG00000173889
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q8NDX5
HGNC ID	HGNC:15682
VEGA ID	OTTHUMG00000158777
String ID	9606.ENSP00000420294
PharmGKB ID	PA134886018

Target gene [PHC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000110	chr3	878	80	75	1033	View
4004175	chr3	9	36	3	48	View
4009576	chr3	8	3		11	View
4016335	chr3				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PHC3 expression and immune infiltrating cell level correlation result in HIV+ samples
PHC3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PHC3 expression and immune infiltrating cell level correlation result in HIV+ samples
PHC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).