HBV Target gene Detail Information

> PHACTR4 Gene Search Result

Gene Information

Gene Name	PHACTR4
Gene ID	65979
Gene Full Name	phosphatase and actin regulator 4
Gene Alias	PPP1R124
Transcripts	ENSG00000204138
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;Intermediate filaments;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q8IZ21
HGNC ID	HGNC:25793
VEGA ID	OTTHUMG00000003541
OMIM ID	608726
String ID	9606.ENSP00000362942
PharmGKB ID	PA134959472

Target gene [PHACTR4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1003841	chr1	60	24	22	106	View
1009679	chr1	15			15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of PHACTR4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PHACTR4 expression: Low -> High
Lollipop of PHACTR4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of PHACTR4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PHACTR4 expression and immune infiltrating cell level correlation result in HBV+ samples
PHACTR4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).