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HBV Target gene Detail Information

> PGR Gene Search Result


Gene Information
Gene Name PGR
Gene ID 5241
Gene Full Name progesterone receptor
Gene Alias PR; NR3C3
Transcripts ENSG00000082175
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Cancer-related genes, FDA approved drug targets, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID P06401
HGNC ID HGNC:8910
VEGA ID OTTHUMG00000167531
OMIM ID 607311
String ID 9606.ENSP00000325120
Drugbank ID BE0000557
Drug (Cytoscape Annotation) Dexamethasone
PharmGKB ID PA266
FDA Approved Drug Anastrozole;Docetaxel;Eribulin;Exemestane;Fulvestrant;Goserelin;Ixabepilone;Lapatinib;Letrozole;Neratinib;Olaparib;Pertuzumab;Ribociclib;Tamoxifen;Trastuzumab
Target gene [PGR] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1010205 chr11 3 10 13 View
1013024 chrX 4 2 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PGR expression and immune infiltrating cell level correlation result in HBV+ samples
PGR expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).