HTLV1 Target gene Detail Information

> PDK2 Gene Search Result

Gene Information

Gene Name	PDK2
Gene ID	5164
Gene Full Name	pyruvate dehydrogenase kinase 2
Gene Alias	PDHK2; PDKII
Transcripts	ENSG00000005882
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;Nucleoplasm;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q15119
HGNC ID	HGNC:8810
VEGA ID	OTTHUMG00000161948
OMIM ID	602525
String ID	9606.ENSP00000420927
Drugbank ID	BE0004348
PharmGKB ID	PA33155

Target gene [PDK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6011474	chr17	20	6		26	View
6015342	chr17	14			14	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PDK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDK2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PDK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDK2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PDK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).