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HBV Target gene Detail Information

> PDGFRA Gene Search Result


Gene Information
Gene Name PDGFRA
Gene ID 5156
Gene Full Name platelet derived growth factor receptor alpha
Gene Alias CD140A; PDGFR2; PDGFR-2
Transcripts ENSG00000134853
Virus HBV
Gene Type protein coding
HPA Location Info Cell Junctions;Nucleoplasm;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID P16234
HGNC ID HGNC:8803
VEGA ID OTTHUMG00000128699
OMIM ID 173490
String ID 9606.ENSP00000257290
Drugbank ID BE0000852
Drug (Cytoscape Annotation) Sorafenib Tosylate;ImatinibMesylate;Nilotinib;Vandetanib;Sunitinib Malate;Pazopanib Hydrochloride;Dasatinib;Axitinib
PharmGKB ID PA33147
FDA Approved Drug Sunitinib;Olaratumab;Avapritinib;Imatinib
Target gene [PDGFRA] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1010620 chr4 11 11 View
1401271 chr4 11 11 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PDGFRA expression and immune infiltrating cell level correlation result in HBV+ samples
PDGFRA expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).