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HBV Target gene Detail Information

> PDE7A Gene Search Result


Gene Information
Gene Name PDE7A
Gene ID 5150
Gene Full Name phosphodiesterase 7A
Gene Alias HCP1; PDE7
Transcripts ENSG00000205268
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID Q13946
HGNC ID HGNC:8791
VEGA ID OTTHUMG00000164469
OMIM ID 171885
String ID 9606.ENSP00000385632
Drugbank ID BE0000706; BE0004922
PharmGKB ID PA33139
Target gene [PDE7A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007153 chr8 28 1 1 30 View
1009493 chr8 15 15 View
1403791 chr8 15 15 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PDE7A expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PDE7A expression: Low -> High
Lollipop of PDE7A expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PDE7A expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PDE7A expression and immune infiltrating cell level correlation result in HBV+ samples
PDE7A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).