HIV Target gene Detail Information

> PDE5A Gene Search Result

Gene Information

Gene Name	PDE5A
Gene ID	8654
Gene Full Name	phosphodiesterase 5A
Gene Alias	CN5A; PDE5; CGB-PDE
Transcripts	ENSG00000138735
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	O76074
HGNC ID	HGNC:8784
VEGA ID	OTTHUMG00000132971
OMIM ID	603310
String ID	9606.ENSP00000347046
Drugbank ID	BE0000182; BE0009789; BE0004922
PharmGKB ID	PA33132

Target gene [PDE5A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013487	chr4	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PDE5A expression and immune infiltrating cell level correlation result in HIV+ samples
PDE5A expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PDE5A expression and immune infiltrating cell level correlation result in HIV+ samples
PDE5A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).