HBV Target gene Detail Information

> PDE3B Gene Search Result

Gene Information

Gene Name	PDE3B
Gene ID	5140
Gene Full Name	phosphodiesterase 3B
Gene Alias	HcGIP1; cGIPDE1
Transcripts	ENSG00000152270
Virus	HBV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted membrane proteins
Uniport_ID	Q13370
HGNC ID	HGNC:8779
VEGA ID	OTTHUMG00000165898
OMIM ID	602047
String ID	9606.ENSP00000282096
Drugbank ID	BE0001223; BE0009789; BE0004922
PharmGKB ID	PA33127

Target gene [PDE3B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002901	chr11	180	8	4	192	View
1008746	chr11	5	6	8	19	View
1013259	chr11	3	2		5	View
1013277	chr11	3	2		5	View
1013328	chr11	3	2		5	View
1013352	chr11	3	2		5	View
1013419	chr11	3	2		5	View
1013982	chr11	3	1		4	View
1016829	chr11	1			1	View
1017104	chr11	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PDE3B expression and immune infiltrating cell level correlation result in HBV+ samples
PDE3B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).