HTLV1 Target gene Detail Information

> PDE1B Gene Search Result

Gene Information

Gene Name	PDE1B
Gene ID	5153
Gene Full Name	phosphodiesterase 1B
Gene Alias	PDE1B1; PDES1B; HEL-S-79p
Transcripts	ENSG00000123360
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q01064
HGNC ID	HGNC:8775
VEGA ID	OTTHUMG00000169844
OMIM ID	171891
String ID	9606.ENSP00000243052
Drugbank ID	BE0003323; BE0009789; BE0004922
PharmGKB ID	PA33123

Target gene [PDE1B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006661	chr12	22	26	17	65	View
6019122	chr12	8			8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PDE1B expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDE1B expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PDE1B expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDE1B expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PDE1B expression and immune infiltrating cell level correlation result in HTLV1+ samples
PDE1B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).