HIV Target gene Detail Information

> PDCD4 Gene Search Result

Gene Information

Gene Name	PDCD4
Gene ID	27250
Gene Full Name	programmed cell death 4
Gene Alias	H731
Transcripts	ENSG00000150593
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q53EL6
HGNC ID	HGNC:8763
VEGA ID	OTTHUMG00000019048
OMIM ID	608610
String ID	9606.ENSP00000280154
PharmGKB ID	PA33113

Target gene [PDCD4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000444	chr10	264	111	85	460	View
4001830	chr10	125	3		128	View
4013840	chr10	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PDCD4 expression and immune infiltrating cell level correlation result in HIV+ samples
PDCD4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PDCD4 expression and immune infiltrating cell level correlation result in HIV+ samples
PDCD4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).