HPV Target gene Detail Information

> PDCD1LG2 Gene Search Result

Gene Information

Gene Name	PDCD1LG2
Gene ID	80380
Gene Full Name	programmed cell death 1 ligand 2
Gene Alias	B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; bA574F11.2
Transcripts	ENSG00000197646
Virus	HPV
Gene Type	protein coding
HPA Location Info	Cytosol;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	Q9BQ51
HGNC ID	HGNC:18731
VEGA ID	OTTHUMG00000019504
OMIM ID	605723
String ID	9606.ENSP00000380855
PharmGKB ID	PA134891547

Target gene [PDCD1LG2] related to VISs

DVID	Chromosome	HM	TFBS	Sum of Overlapped Records	Detail
5001609	chr9	24	1	25	View
5003592	chr9	2	1	3	View
5003593	chr9	2	1	3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of PDCD1LG2 expression and immune infiltrating cell level correlation result in HPV+ samples
PDCD1LG2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662