HTLV1 Target gene Detail Information

> PCSK2 Gene Search Result

Gene Information

Gene Name	PCSK2
Gene ID	5126
Gene Full Name	proprotein convertase subtilisin/kexin type 2
Gene Alias	PC2; NEC2; SPC2; NEC 2; NEC-2
Transcripts	ENSG00000125851
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;Predicted to be secreted;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P16519
HGNC ID	HGNC:8744
VEGA ID	OTTHUMG00000031941
OMIM ID	162151
String ID	9606.ENSP00000262545
Drugbank ID	BE0002124
PharmGKB ID	PA33091

Target gene [PCSK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6022075	chr20	1	4		5	View
6023026	chr20	1	3		4	View
6027552	chr20	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PCSK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCSK2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PCSK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCSK2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PCSK2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCSK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).