HBV Target gene Detail Information

> PCSK1 Gene Search Result

Gene Information

Gene Name	PCSK1
Gene ID	5122
Gene Full Name	proprotein convertase subtilisin/kexin type 1
Gene Alias	PC1; PC3; NEC1; SPC3; BMIQ12
Transcripts	ENSG00000175426
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P29120
HGNC ID	HGNC:8743
VEGA ID	OTTHUMG00000122089
OMIM ID	162150
String ID	9606.ENSP00000308024
Drugbank ID	BE0002125
PharmGKB ID	PA33089
FDA Approved Drug	Setmelanotide

Target gene [PCSK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1011398	chr5	5	4		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PCSK1 expression and immune infiltrating cell level correlation result in HBV+ samples
PCSK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).