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HBV Target gene Detail Information

> PCLO Gene Search Result


Gene Information
Gene Name PCLO
Gene ID 27445
Gene Full Name piccolo presynaptic cytomatrix protein
Gene Alias ACZ; PCH3
Transcripts ENSG00000186472
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q9Y6V0
HGNC ID HGNC:13406
VEGA ID OTTHUMG00000154853
OMIM ID 604918
String ID 9606.ENSP00000334319
PharmGKB ID PA33072
Target gene [PCLO] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002886 chr7 50 75 68 193 View
1019495 chr7 0 View
1402036 chr7 50 75 68 193 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PCLO expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PCLO expression: Low -> High
Lollipop of PCLO expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PCLO expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PCLO expression and immune infiltrating cell level correlation result in HBV+ samples
PCLO expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).