HTLV1 Target gene Detail Information

> PCBD2 Gene Search Result

Gene Information

Gene Name	PCBD2
Gene ID	84105
Gene Full Name	pterin-4 alpha-carbinolamine dehydratase 2
Gene Alias	PHS2; DCOH2; DCOHM
Transcripts	ENSG00000132570
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9H0N5
HGNC ID	HGNC:24474
VEGA ID	OTTHUMG00000163070
OMIM ID	609836
String ID	9606.ENSP00000421544
PharmGKB ID	PA142671197

Target gene [PCBD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6008292	chr5	42	4		46	View
6014814	chr5	15			15	View
6100051	chr5	186	280	435	901	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of PCBD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCBD2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of PCBD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCBD2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of PCBD2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PCBD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).