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HTLV1 Target gene Detail Information

> PC Gene Search Result


Gene Information
Gene Name PC
Gene ID 5091
Gene Full Name pyruvate carboxylase
Gene Alias PCB
Transcripts ENSG00000173599
Virus HTLV1
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID P11498
HGNC ID HGNC:8636
VEGA ID OTTHUMG00000167099
OMIM ID 608786
String ID 9606.ENSP00000377532
Drugbank ID BE0000698
PharmGKB ID PA32975
Target gene [PC] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6001709 chr2 23 266 73 362 View
6005722 chr6 19 10 53 82 View
6006029 chr3 76 76 View
6006530 chr14 56 9 2 67 View
6009824 chr11 31 3 34 View
6012483 chr6 21 1 22 View
6013203 chr4 17 3 20 View
6016312 chr4 10 2 12 View
6019751 chr4 4 3 7 View
6023287 chr4 4 4 View
6032019 chr6 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PC expression and immune infiltrating cell level correlation result in HTLV1+ samples
PC expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PC expression and immune infiltrating cell level correlation result in HTLV1+ samples
PC expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PC expression and immune infiltrating cell level correlation result in HTLV1+ samples
PC expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).