HIV Target gene Detail Information

> PBRM1 Gene Search Result

Gene Information

Gene Name	PBRM1
Gene ID	55193
Gene Full Name	polybromo 1
Gene Alias	PB1; BAF180
Transcripts	ENSG00000163939
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q86U86
HGNC ID	HGNC:30064
VEGA ID	OTTHUMG00000152663
OMIM ID	606083
String ID	9606.ENSP00000378307
PharmGKB ID	PA162398846

Target gene [PBRM1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004980	chr3	33	4		37	View
4005862	chr3	28	1		29	View
4011093	chr3	5		2	7	View
4011919	chr3	1	5		6	View
4012311	chr3	5			5	View
4012312	chr3	5			5	View
4012313	chr3	5			5	View
4015374	chr3			1	1	View
4016516	chr3				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PBRM1 expression and immune infiltrating cell level correlation result in HIV+ samples
PBRM1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PBRM1 expression and immune infiltrating cell level correlation result in HIV+ samples
PBRM1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).