HIV Target gene Detail Information

> PARP2 Gene Search Result

Gene Information

Gene Name	PARP2
Gene ID	10038
Gene Full Name	poly(ADP-ribose) polymerase 2
Gene Alias	ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2
Transcripts	ENSG00000129484
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nucleoli;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	Q9UGN5
HGNC ID	HGNC:272
VEGA ID	OTTHUMG00000166106
OMIM ID	607725
String ID	9606.ENSP00000250416
Drugbank ID	BE0003798
PharmGKB ID	PA24592

Target gene [PARP2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000029	chr14	2087	49	10	2146	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PARP2 expression and immune infiltrating cell level correlation result in HIV+ samples
PARP2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PARP2 expression and immune infiltrating cell level correlation result in HIV+ samples
PARP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).