HIV Target gene Detail Information

> PARP1 Gene Search Result

Gene Information

Gene Name	PARP1
Gene ID	142
Gene Full Name	poly(ADP-ribose) polymerase 1
Gene Alias	PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
Transcripts	ENSG00000143799
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nucleoli;
HPA Protein Class Info	Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P09874
HGNC ID	HGNC:270
VEGA ID	OTTHUMG00000037556
OMIM ID	173870
String ID	9606.ENSP00000355759
Drugbank ID	BE0001717
PharmGKB ID	PA32

Target gene [PARP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003106	chr1	27	33	9	69	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PARP1 expression and immune infiltrating cell level correlation result in HIV+ samples
PARP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PARP1 expression and immune infiltrating cell level correlation result in HIV+ samples
PARP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).