HIV Target gene Detail Information

> PARN Gene Search Result

Gene Information

Gene Name	PARN
Gene ID	5073
Gene Full Name	poly(A)-specific ribonuclease
Gene Alias	DAN; DKCB6; PFBMFT4
Transcripts	ENSG00000274829
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	O95453
HGNC ID	HGNC:8609
VEGA ID	OTTHUMG00000191069
OMIM ID	604212
String ID	9606.ENSP00000387911
PharmGKB ID	PA32949

Target gene [PARN] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000238	chr16	94	245	326	665	View
4000929	chr16	95	76	75	246	View
4002052	chr16	10	7	98	115	View
4003898	chr16	42	10		52	View
4004932	chr16	36	2		38	View
4005675	chr16	30			30	View
4007166	chr16	14	6		20	View
4008681	chr16	11	2	1	14	View
4012903	chr16	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PARN expression and immune infiltrating cell level correlation result in HIV+ samples
PARN expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PARN expression and immune infiltrating cell level correlation result in HIV+ samples
PARN expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).