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HBV Target gene Detail Information

> PAPPA2 Gene Search Result


Gene Information
Gene Name PAPPA2
Gene ID 60676
Gene Full Name pappalysin 2
Gene Alias PAPPE; PLAC3; PAPP-E; PAPP-A2
Transcripts ENSG00000116183
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;Vesicles;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID Q9BXP8
HGNC ID HGNC:14615
VEGA ID OTTHUMG00000035025
String ID 9606.ENSP00000356634
PharmGKB ID PA33373
Target gene [PAPPA2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003492 chr1 34 88 9 131 View
1003713 chr1 26 78 16 120 View
1005614 chr1 5 44 2 51 View
1011434 chr1 9 9 View
1011435 chr1 9 9 View
1013115 chr1 3 2 5 View
1402150 chr1 3 2 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of PAPPA2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
PAPPA2 expression: Low -> High
Lollipop of PAPPA2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of PAPPA2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of PAPPA2 expression and immune infiltrating cell level correlation result in HBV+ samples
PAPPA2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).