HBV Target gene Detail Information

> PAPPA Gene Search Result

Gene Information

Gene Name	PAPPA
Gene ID	5069
Gene Full Name	pappalysin 1
Gene Alias	PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
Transcripts	ENSG00000182752
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins
Uniport_ID	Q13219
HGNC ID	HGNC:8602
VEGA ID	OTTHUMG00000021045
OMIM ID	176385
String ID	9606.ENSP00000330658
Drugbank ID	BE0008956
PharmGKB ID	PA32935

Target gene [PAPPA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1007982	chr9	12	9	2	23	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of PAPPA expression and immune infiltrating cell level correlation result in HBV+ samples
PAPPA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).