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HTLV1 Target gene Detail Information

> PAK3 Gene Search Result


Gene Information
Gene Name PAK3
Gene ID 5063
Gene Full Name p21 (RAC1) activated kinase 3
Gene Alias ARA; bPAK; MRX30; MRX47; OPHN3; PAK-3; PAK3beta; beta-PAK
Transcripts ENSG00000077264
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;
HPA Protein Class Info Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID O75914
HGNC ID HGNC:8592
VEGA ID OTTHUMG00000022202
OMIM ID 300142
String ID 9606.ENSP00000353864
Drugbank ID BE0009461
PharmGKB ID PA32919
Target gene [PAK3] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 23622267 S150A
Tax
 View
2 23622267 S258A
Tax
 View
3 23622267 C23S
Tax
 View

Target gene [PAK3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6003140 chrX 3 128 49 180 View
6023111 chrX 4 4 View
6024936 chrX 3 3 View
6030583 chrX 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of PAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PAK3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of PAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PAK3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of PAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
PAK3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).