HIV Target gene Detail Information

> PAK1 Gene Search Result

Gene Information

Gene Name	PAK1
Gene ID	5058
Gene Full Name	p21 (RAC1) activated kinase 1
Gene Alias	IDDMSSD; PAKalpha
Transcripts	ENSG00000149269
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	Q13153
HGNC ID	HGNC:8590
VEGA ID	OTTHUMG00000165138
OMIM ID	602590
String ID	9606.ENSP00000278568
Drugbank ID	BE0009459
PharmGKB ID	PA32917

Target gene [PAK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008476	chr11	15			15	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PAK1 expression and immune infiltrating cell level correlation result in HIV+ samples
PAK1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PAK1 expression and immune infiltrating cell level correlation result in HIV+ samples
PAK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).