HIV Target gene Detail Information

> PAFAH1B1 Gene Search Result

Gene Information

Gene Name	PAFAH1B1
Gene ID	5048
Gene Full Name	platelet activating factor acetylhydrolase 1b regulatory subunit 1
Gene Alias	MDS; LIS1; LIS2; MDCR; NudF; PAFAH
Transcripts	ENSG00000007168
Virus	HIV
Gene Type	protein coding
HPA Location Info	Centrosome;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P43034
HGNC ID	HGNC:8574
VEGA ID	OTTHUMG00000177574
OMIM ID	601545
String ID	9606.ENSP00000380378
PharmGKB ID	PA32905

Target gene [PAFAH1B1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001550	chr17	64	87		151	View
4001605	chr17	146		1	147	View
4005977	chr17	20	8		28	View
4006187	chr17	7	19		26	View
4007403	chr17	19			19	View
4008338	chr17	1	14		15	View
4008810	chr17	12	2		14	View
4009824	chr17	10			10	View
4010794	chr17	7	1		8	View
4011583	chr17	4	2		6	View
4011889	chr17	6			6	View
4012727	chr17	3	1		4	View
4012728	chr17	4			4	View
4012910	chr17	3	1		4	View
4013168	chr17	1		3	4	View
4013441	chr17	3			3	View
4015300	chr17		1		1	View
4015520	chr17	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of PAFAH1B1 expression and immune infiltrating cell level correlation result in HIV+ samples
PAFAH1B1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of PAFAH1B1 expression and immune infiltrating cell level correlation result in HIV+ samples
PAFAH1B1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).