HBV Target gene Detail Information

> P4HB Gene Search Result

Gene Information

Gene Name	P4HB
Gene ID	5034
Gene Full Name	prolyl 4-hydroxylase subunit beta
Gene Alias	DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta
Transcripts	ENSG00000185624
Virus	HBV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;Predicted to be secreted;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P07237
HGNC ID	HGNC:8548
VEGA ID	OTTHUMG00000150269
OMIM ID	176790
String ID	9606.ENSP00000327801
Drugbank ID	BE0002467
PharmGKB ID	PA32876

Target gene [P4HB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001296	chr17	733	68		801	View
1003098	chr17	27	56	84	167	View
1004356	chr17	48	34	2	84	View
1005120	chr17	52	9		61	View
1402956	chr17	25	18		43	View
1402957	chr17	733	68		801	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of P4HB expression and immune infiltrating cell level correlation result in HBV+ samples
P4HB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).