HIV Target gene Detail Information

> P4HA1 Gene Search Result

Gene Information

Gene Name	P4HA1
Gene ID	5033
Gene Full Name	prolyl 4-hydroxylase subunit alpha 1
Gene Alias	P4HA
Transcripts	ENSG00000122884
Virus	HIV
Gene Type	protein coding
HPA Location Info	Endoplasmic reticulum;Mitochondria;Vesicles;
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P13674
HGNC ID	HGNC:8546
VEGA ID	OTTHUMG00000018449
OMIM ID	176710
String ID	9606.ENSP00000263556
Drugbank ID	BE0000060
PharmGKB ID	PA32874

Target gene [P4HA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000813	chr10	271	4		275	View
4008126	chr10	14	2		16	View
4009199	chr10	12			12	View
4010105	chr10	7	3		10	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of P4HA1 expression and immune infiltrating cell level correlation result in HIV+ samples
P4HA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of P4HA1 expression and immune infiltrating cell level correlation result in HIV+ samples
P4HA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).