HIV Target gene Detail Information

> P2RX7 Gene Search Result

Gene Information

Gene Name	P2RX7
Gene ID	5027
Gene Full Name	purinergic receptor P2X 7
Gene Alias	P2X7
Transcripts	ENSG00000089041
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Transporters
Uniport_ID	Q99572
HGNC ID	HGNC:8537
VEGA ID	OTTHUMG00000169153
OMIM ID	602566
String ID	9606.ENSP00000330696
Drugbank ID	BE0009999
PharmGKB ID	PA32866

Target gene [P2RX7] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008069	chr12	13	2	1	16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of P2RX7 expression and immune infiltrating cell level correlation result in HIV+ samples
P2RX7 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of P2RX7 expression and immune infiltrating cell level correlation result in HIV+ samples
P2RX7 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).