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HBV Target gene Detail Information

> OTC Gene Search Result


Gene Information
Gene Name OTC
Gene ID 5009
Gene Full Name ornithine carbamoyltransferase
Gene Alias OCTD
Transcripts ENSG00000036473
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID P00480
HGNC ID HGNC:8512
VEGA ID OTTHUMG00000022727
OMIM ID 300461
String ID 9606.ENSP00000039007
Drugbank ID BE0000306
PharmGKB ID PA32840
FDA Approved Drug Sodium Phenylbutyrate
Target gene [OTC] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1012417 chrX 6 1 7 View
1016024 chrX 1 1 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of OTC expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
OTC expression: Low -> High
Lollipop of OTC expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of OTC expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of OTC expression and immune infiltrating cell level correlation result in HBV+ samples
OTC expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).