HBV Target gene Detail Information

> OSBPL3 Gene Search Result


Gene Information
Gene Name OSBPL3
Gene ID 26031
Gene Full Name oxysterol binding protein like 3
Gene Alias ORP3; ORP-3; OSBP3
Transcripts ENSG00000070882
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoli;
HPA Protein Class Info Plasma proteins, Predicted intracellular proteins
Uniport_ID Q9H4L5
HGNC ID HGNC:16370
VEGA ID OTTHUMG00000023277
OMIM ID 606732
String ID 9606.ENSP00000315410
PharmGKB ID PA32828
Target gene [OSBPL3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003008 chr7 130 32 15 177 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of OSBPL3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
OSBPL3 expression: Low -> High
Lollipop of OSBPL3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of OSBPL3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of OSBPL3 expression and immune infiltrating cell level correlation result in HBV+ samples
OSBPL3 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).