HBV Target gene Detail Information

> ORMDL3 Gene Search Result


Gene Information
Gene Name ORMDL3
Gene ID 94103
Gene Full Name ORMDL sphingolipid biosynthesis regulator 3
Transcripts ENSG00000172057
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Predicted membrane proteins
Uniport_ID Q8N138
HGNC ID HGNC:16038
VEGA ID OTTHUMG00000133249
OMIM ID 610075
String ID 9606.ENSP00000377724
PharmGKB ID PA32821
Target gene [ORMDL3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003298 chr17 106 29 14 149 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of ORMDL3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
ORMDL3 expression: Low -> High
Lollipop of ORMDL3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of ORMDL3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ORMDL3 expression and immune infiltrating cell level correlation result in HBV+ samples
ORMDL3 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).