HPV Target gene Detail Information

> ORC2 Gene Search Result

Gene Information

Gene Name	ORC2
Gene ID	4999
Gene Full Name	origin recognition complex subunit 2
Gene Alias	ORC2L
Transcripts	ENSG00000115942
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q13416
HGNC ID	HGNC:8488
VEGA ID	OTTHUMG00000132783
OMIM ID	601182
String ID	9606.ENSP00000234296
PharmGKB ID	PA32809

Target gene [ORC2] related to VISs

DVID	Chromosome	HM	TFBS	Sum of Overlapped Records	Detail
5001861	chr2	21		21	View
5001979	chr22	7	11	18	View
5403362	chr22	1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of ORC2 expression and immune infiltrating cell level correlation result in HPV+ samples
ORC2 expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of ORC2 expression and immune infiltrating cell level correlation result in HPV+ samples
ORC2 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of ORC2 expression and immune infiltrating cell level correlation result in HPV+ samples
ORC2 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of ORC2 expression and immune infiltrating cell level correlation result in HPV+ samples
ORC2 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of ORC2 expression and immune infiltrating cell level correlation result in HPV+ samples
ORC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662