HIV Target gene Detail Information

> OPTN Gene Search Result

Gene Information

Gene Name	OPTN
Gene ID	10133
Gene Full Name	optineurin
Gene Alias	NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
Transcripts	ENSG00000123240
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q96CV9
HGNC ID	HGNC:17142
VEGA ID	OTTHUMG00000017690
OMIM ID	602432
String ID	9606.ENSP00000368022
PharmGKB ID	PA31948

Target gene [OPTN] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004489	chr10	27	16		43	View
4009197	chr10	12			12	View
4010543	chr10	8			8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of OPTN expression and immune infiltrating cell level correlation result in HIV+ samples
OPTN expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of OPTN expression and immune infiltrating cell level correlation result in HIV+ samples
OPTN expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).