HTLV1 Target gene Detail Information

> OPRM1 Gene Search Result

Gene Information

Gene Name	OPRM1
Gene ID	4988
Gene Full Name	opioid receptor mu 1
Gene Alias	MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Transcripts	ENSG00000112038
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Uniport_ID	P35372
HGNC ID	HGNC:8156
VEGA ID	OTTHUMG00000015870
OMIM ID	600018
String ID	9606.ENSP00000394624
Drugbank ID	BE0000770
PharmGKB ID	PA31945

Target gene [OPRM1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6016816	chr6	11			11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of OPRM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OPRM1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of OPRM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OPRM1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of OPRM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OPRM1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).