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HTLV1 Target gene Detail Information

> OGG1 Gene Search Result


Gene Information
Gene Name OGG1
Gene ID 4968
Gene Full Name 8-oxoguanine DNA glycosylase
Gene Alias HMMH; MUTM; OGH1; HOGG1
Transcripts ENSG00000114026
Virus HTLV1
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID O15527
HGNC ID HGNC:8125
VEGA ID OTTHUMG00000097091
OMIM ID 601982
String ID 9606.ENSP00000306561
PharmGKB ID PA31912
Target gene [OGG1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000647 chr3 997 40 4 1041 View
6003573 chr3 81 5 66 152 View
6017694 chr3 4 6 10 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of OGG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OGG1 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of OGG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OGG1 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of OGG1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
OGG1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).