HIV Target gene Detail Information

> OAS3 Gene Search Result

Gene Information

Gene Name	OAS3
Gene ID	4940
Gene Full Name	2'-5'-oligoadenylate synthetase 3
Gene Alias	p100; p100OAS
Transcripts	ENSG00000111331
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q9Y6K5
HGNC ID	HGNC:8088
VEGA ID	OTTHUMG00000169795
OMIM ID	603351
String ID	9606.ENSP00000228928
PharmGKB ID	PA31877

Target gene [OAS3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4005781	chr12	24	1	4	29	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of OAS3 expression and immune infiltrating cell level correlation result in HIV+ samples
OAS3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of OAS3 expression and immune infiltrating cell level correlation result in HIV+ samples
OAS3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).