HTLV1 Target gene Detail Information

> NXNL2 Gene Search Result

Gene Information

Gene Name	NXNL2
Gene ID	158046
Gene Full Name	nucleoredoxin like 2
Gene Alias	RDCVF2; RdCVF2L; C9orf121
Transcripts	ENSG00000130045
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q5VZ03
HGNC ID	HGNC:30482
VEGA ID	OTTHUMG00000020170
OMIM ID	615299
String ID	9606.ENSP00000365014
PharmGKB ID	PA162398384

Target gene [NXNL2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010489	chr9	24	4	3	31	View
6021370	chr9	6			6	View
6022030	chr9	4	1		5	View
6026066	chr9	2			2	View
6026082	chr9	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of NXNL2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NXNL2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of NXNL2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NXNL2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).