HIV Target gene Detail Information

> NUMA1 Gene Search Result

Gene Information

Gene Name	NUMA1
Gene ID	4926
Gene Full Name	nuclear mitotic apparatus protein 1
Gene Alias	NUMA; NMP-22
Transcripts	ENSG00000137497
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q14980
HGNC ID	HGNC:8059
VEGA ID	OTTHUMG00000167697
OMIM ID	164009
String ID	9606.ENSP00000377298
PharmGKB ID	PA31844

Target gene [NUMA1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000023	chr11	653	893	881	2427	View
4001206	chr11	111	62	27	200	View
4001501	chr11	29	119	9	157	View
4003559	chr11	52	7		59	View
4003560	chr11	30	24	5	59	View
4003829	chr11	48	6		54	View
4008728	chr11	14			14	View
4009643	chr11	10	1		11	View
4012199	chr11	4	1		5	View
4013260	chr11	4			4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NUMA1 expression and immune infiltrating cell level correlation result in HIV+ samples
NUMA1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NUMA1 expression and immune infiltrating cell level correlation result in HIV+ samples
NUMA1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).