HIV Target gene Detail Information

> NUCKS1 Gene Search Result

Gene Information

Gene Name	NUCKS1
Gene ID	64710
Gene Full Name	nuclear casein kinase and cyclin dependent kinase substrate 1
Gene Alias	JC7; NUCKS
Transcripts	ENSG00000069275
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nucleoli;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9H1E3
HGNC ID	HGNC:29923
VEGA ID	OTTHUMG00000035996
OMIM ID	611912
String ID	9606.ENSP00000356110
PharmGKB ID	PA142671244

Target gene [NUCKS1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004965	chr1	26	11		37	View
4007719	chr1	12	6		18	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NUCKS1 expression and immune infiltrating cell level correlation result in HIV+ samples
NUCKS1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NUCKS1 expression and immune infiltrating cell level correlation result in HIV+ samples
NUCKS1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).