HIV Target gene Detail Information

> NSMCE1 Gene Search Result

Gene Information

Gene Name	NSMCE1
Gene ID	197370
Gene Full Name	NSE1 homolog, SMC5-SMC6 complex component
Gene Alias	NSE1
Transcripts	ENSG00000169189
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Vesicles;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q8WV22
HGNC ID	HGNC:29897
VEGA ID	OTTHUMG00000131674
OMIM ID	617263
String ID	9606.ENSP00000355077
PharmGKB ID	PA134943761

Target gene [NSMCE1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002141	chr16	90	15	5	110	View
4003923	chr16	47	5		52	View
4006682	chr16	3	3	17	23	View
4012537	chr16	3		2	5	View
4013097	chr16	3	1		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NSMCE1 expression and immune infiltrating cell level correlation result in HIV+ samples
NSMCE1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NSMCE1 expression and immune infiltrating cell level correlation result in HIV+ samples
NSMCE1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).