HTLV1 Target gene Detail Information

> NRK Gene Search Result

Gene Information

Gene Name	NRK
Gene ID	203447
Gene Full Name	Nik related kinase
Gene Alias	NESK
Transcripts	ENSG00000123572
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q7Z2Y5
HGNC ID	HGNC:25391
VEGA ID	OTTHUMG00000022143
OMIM ID	300791
String ID	9606.ENSP00000434830
PharmGKB ID	PA134869113

Target gene [NRK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6007707	chr3	25	27		52	View
6016441	chrX	3	5	4	12	View
6019351	chr3	6	2		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of NRK expression and immune infiltrating cell level correlation result in HTLV1+ samples
NRK expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of NRK expression and immune infiltrating cell level correlation result in HTLV1+ samples
NRK expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of NRK expression and immune infiltrating cell level correlation result in HTLV1+ samples
NRK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).