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HBV Target gene Detail Information

> NRG3 Gene Search Result


Gene Information
Gene Name NRG3
Gene ID 10718
Gene Full Name neuregulin 3
Gene Alias HRG3; pro-NRG3
Transcripts ENSG00000185737
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID P56975
HGNC ID HGNC:7999
VEGA ID OTTHUMG00000018626
OMIM ID 605533
String ID 9606.ENSP00000361214
PharmGKB ID PA31778
Target gene [NRG3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005940 chr10 45 45 View
1011679 chr10 1 1 6 8 View
1015260 chr10 2 2 View
1017558 chr10 0 View
1019619 chr10 0 View
1401780 chr10 45 45 View
1402831 chr10 2 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of NRG3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
NRG3 expression: Low -> High
Lollipop of NRG3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of NRG3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NRG3 expression and immune infiltrating cell level correlation result in HBV+ samples
NRG3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).