Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> NRG1 Gene Search Result


Gene Information
Gene Name NRG1
Gene ID 3084
Gene Full Name neuregulin 1
Gene Alias GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2
Transcripts ENSG00000157168
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID Q02297
HGNC ID HGNC:7997
VEGA ID OTTHUMG00000163918
OMIM ID 142445
String ID 9606.ENSP00000384620
PharmGKB ID PA31776
Target gene [NRG1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002817 chr8 185 11 6 202 View
1002864 chr8 28 108 61 197 View
1005118 chr8 35 16 10 61 View
1010805 chr8 11 11 View
1011776 chr8 7 1 8 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of NRG1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
NRG1 expression: Low -> High
Lollipop of NRG1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of NRG1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NRG1 expression and immune infiltrating cell level correlation result in HBV+ samples
NRG1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).