HIV Target gene Detail Information

> NRAS Gene Search Result

Gene Information

Gene Name	NRAS
Gene ID	4893
Gene Full Name	NRAS proto-oncogene, GTPase
Gene Alias	NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1
Transcripts	ENSG00000213281
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, RAS pathway related proteins
Gene Function	Oncogene
Uniport_ID	P01111
HGNC ID	HGNC:7989
VEGA ID	OTTHUMG00000012059
OMIM ID	164790
String ID	9606.ENSP00000358548
PharmGKB ID	PA31768

Target gene [NRAS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4014302	chr1	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NRAS expression and immune infiltrating cell level correlation result in HIV+ samples
NRAS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NRAS expression and immune infiltrating cell level correlation result in HIV+ samples
NRAS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).