HTLV1 Target gene Detail Information

> NR4A1 Gene Search Result

Gene Information

Gene Name	NR4A1
Gene ID	3164
Gene Full Name	nuclear receptor subfamily 4 group A member 1
Gene Alias	HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77
Transcripts	ENSG00000123358
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nuclear membrane;
HPA Protein Class Info	Nuclear receptors, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	P22736
HGNC ID	HGNC:7980
VEGA ID	OTTHUMG00000150393
OMIM ID	139139
String ID	9606.ENSP00000440864
PharmGKB ID	PA31761

Target gene [NR4A1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004799	chr12	103		1	104	View
6004800	chr12	103		1	104	View
6006920	chr12	61		1	62	View
6008231	chr12	44		3	47	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of NR4A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NR4A1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of NR4A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NR4A1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of NR4A1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
NR4A1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).