HIV Target gene Detail Information

> NR3C1 Gene Search Result

Gene Information

Gene Name	NR3C1
Gene ID	2908
Gene Full Name	nuclear receptor subfamily 3 group C member 1
Gene Alias	GR; GCR; GRL; GCCR; GCRST
Transcripts	ENSG00000113580
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Mitochondria;
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors
Uniport_ID	P04150
HGNC ID	HGNC:7978
VEGA ID	OTTHUMG00000129677
OMIM ID	138040
String ID	9606.ENSP00000231509
Drugbank ID	BE0000794
PharmGKB ID	PA181

Target gene [NR3C1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006092	chr5	10	11	6	27	View
4006386	chr5	18	7		25	View
4006421	chr5	8	17		25	View
4009092	chr5	2	11		13	View
4012644	chr5	1	3		4	View
4013330	chr5	2	2		4	View
4014231	chr5		2		2	View
4014232	chr5		1	1	2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NR3C1 expression and immune infiltrating cell level correlation result in HIV+ samples
NR3C1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NR3C1 expression and immune infiltrating cell level correlation result in HIV+ samples
NR3C1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).