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HBV Target gene Detail Information

> NPM1 Gene Search Result


Gene Information
Gene Name NPM1
Gene ID 4869
Gene Full Name nucleophosmin 1
Gene Alias B23; NPM
Transcripts ENSG00000181163
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli rim;Nucleoplasm;
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins
Gene Function Suppressor gene & Oncogene
Uniport_ID P06748
HGNC ID HGNC:7910
VEGA ID OTTHUMG00000130465
OMIM ID 164040
String ID 9606.ENSP00000296930
Drugbank ID BE0009028
PharmGKB ID PA31712
FDA Approved Drug Midostaurin;Venetoclax
Target gene [NPM1] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 15564475 I97D
C
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of NPM1 expression and immune infiltrating cell level correlation result in HBV+ samples
NPM1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).