HIV Target gene Detail Information

> NPC2 Gene Search Result

Gene Information

Gene Name	NPC2
Gene ID	10577
Gene Full Name	NPC intracellular cholesterol transporter 2
Gene Alias	HE1; EDDM1
Transcripts	ENSG00000119655
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Uniport_ID	P61916
HGNC ID	HGNC:14537
VEGA ID	OTTHUMG00000171212
OMIM ID	601015
String ID	9606.ENSP00000451112
PharmGKB ID	PA31700

Target gene [NPC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4015272	chr14	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NPC2 expression and immune infiltrating cell level correlation result in HIV+ samples
NPC2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NPC2 expression and immune infiltrating cell level correlation result in HIV+ samples
NPC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).