HIV Target gene Detail Information

> NOTCH1 Gene Search Result

Gene Information

Gene Name	NOTCH1
Gene ID	4851
Gene Full Name	notch 1
Gene Alias	hN1; AOS5; TAN1; AOVD1
Transcripts	ENSG00000148400
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters
Gene Function	Suppressor gene & Oncogene
Uniport_ID	P46531
HGNC ID	HGNC:7881
VEGA ID	OTTHUMG00000020935
OMIM ID	190198
String ID	9606.ENSP00000277541
PharmGKB ID	PA31683

Target gene [NOTCH1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001948	chr9	77	44		121	View
4003356	chr9	42	4	17	63	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NOTCH1 expression and immune infiltrating cell level correlation result in HIV+ samples
NOTCH1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NOTCH1 expression and immune infiltrating cell level correlation result in HIV+ samples
NOTCH1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).