HIV Target gene Detail Information

> NOD2 Gene Search Result

Gene Information

Gene Name	NOD2
Gene ID	64127
Gene Full Name	nucleotide binding oligomerization domain containing 2
Gene Alias	CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1
Transcripts	ENSG00000167207
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Golgi apparatus;
HPA Protein Class Info	Disease related genes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID	Q9HC29
HGNC ID	HGNC:5331
VEGA ID	OTTHUMG00000133171
OMIM ID	605956
String ID	9606.ENSP00000300589
Drugbank ID	BE0009291; BE0009323
PharmGKB ID	PA26074

Target gene [NOD2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000265	chr16	291	202	127	620	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of NOD2 expression and immune infiltrating cell level correlation result in HIV+ samples
NOD2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of NOD2 expression and immune infiltrating cell level correlation result in HIV+ samples
NOD2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).